The ubiquitin-like protein NEDD8/Rub1 is initially translated as a precursor and undergoes maturation before becoming functional, a process mediated by the ubiquitin hydrolase UCHL3/Yuh1.Across studied organisms, the mature form of NEDD8/Rub1 modifies cullins, the central subunits of CRLs.NEDD8/Rub1 modification typically enhances CRL-mediated ubiq
Switch-reference has recently been argued to be the result of clausal functional heads entering into Agree with two nearby noun phrases, creating pointers to those noun phrases but not actually copying their morphosyntactic features.Instead, the semantic component interprets the pointers as referential dependency holding between pointed-to noun phr
While actions leading to environmental degradation already have global consequences threatening the very existence of humanity, the war in Ukraine has once again proved the effectiveness of existing international environmental protection mechanisms.The purpose of this study is to analyze existing international environmental protection mechanisms fr
Recent advances in modeling oxygen supply to cortical brain tissue have begun to elucidate the functional mechanisms of neurovascular coupling.While the principal mechanisms of blood flow regulation after neuronal firing are generally known, mechanistic hemodynamic simulations cannot yet pinpoint the exact spatial and temporal coordination between
Introduction: the study emphasizes the process of training the family professional with regard to the legal regulation of custody and care of children in the Cuban Family Code and, in this sense, seeks to overcome the current approach Gender equality, which does not provide equal opportunities for men and women, from the perspective of equity.Objec